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Oral diseases affect over 3.6 billion people globally and are increasingly linked to cardiovascular, metabolic, respiratory, and neurodegenerative diseases. Meanwhile, the $8.5B clear aligner market still relies on passive devices that create enclosed environments promoting bacterial growth and oral dysbiosis, while toothpaste and mouthwash provide only temporary protection. Developed with CSEM, Actival’s patented Active Aligners and Active Splints integrate microfluidic channels enabling controlled, localized, and sustained delivery of antibacterial, fluoride/calcium, and therapeutic agents directly to high-risk areas, supporting continuous oral care, enamel remineralization, and microbiome balance. It transforms passive devices into personalized preventive therapy daily.